The fundamental scientific results of NGC:
The result of many years of theoretical and
experimental research by NGC specialists in the field of aging prevention and
anti-aging medicine were:
"Cellular
hypercycle"
- the development of systemic mechanisms for the interaction of cell
populations, their growth and regulation, the basis of the systemic
organization of multicellular, the basis of a new
theory of immunity and a new immuno-regulatory theory
of aging.
"General
theory of health", which fits into a single holistic scheme of
representation of the General Theory of human pathology and Ecology.
The "Systemic
Theory of Aging" is the
result of systematization and unification of the world's leading theories of
aging and the main mechanisms of aging, summarizing the achievements in this
field of world-renowned scientists in the field of gerontology, valeology and general pathology: D. Harman (Theory of free
radicals); L. Orgel (Catastrophe of errors); V. Frolkis (Gene Regulatory Theory aging, Aging as stress); V.
Dilman (Elevation theory of aging); A. Ado and A. Speransky (General theory of pathology) and a number of
others. The system theory considers the aging process holistically, structures
it, determines the fundamental cause of aging – the law of increasing entropy
in not fully open systems, identifies the main basic aging processes, typical
syndromes and mechanisms of aging, which in turn allows us to determine the
main principles, schemes, ways and means of
influencing aging.
Based on this
theory, a method of systemic diagnostics of aging has been developed (hardware
and software complex and computer system "Diagnostics of aging: bioage" (Certificate of registration of a computer
program. Ru No. 2007614122, 2007)),
as well as the methodology of systemic geroprophylaxis
and bioactivation.
The "Immuno-regulatory theory of aging" is a new look at one of the
main, and for a number of reasons, the main mechanism of aging. The theory is
based on domestic scientific works registered as a discovery (A.G. Babaeva et al.). It describes the cause of the main
mechanism of aging (decrease in the growth potential of cells with age) as a
result of changes in the regulatory hypothalamic centers of the brain.
Peripheral mechanisms of such regulation have been experimentally discovered –
blood regulatory factors in young animals acting through special populations of
T-lymphocytes. A patent has been
obtained for a method of diagnosing such regulatory factors (Ru No. 1481689).
Based on this theory, new diagnostic methods, tools
and drugs for the effects on aging are being developed. In particular,
experimental effects on the system of regulation of cellular growth allowed for
several days to restore the growth potential of tissue in old animals to the
level of young ones (a.c. A method
for restoring the cellular growth potential of tissues decreasing with age
(tissue rejuvenation). The patent of
A number of original mathematical models of
aging processes in a single living organism and in a population: "Model of
functional harmony", "Model of cellular growth", "Model of
dynamics of viability and risk of human death", etc. The main achievements
obtained by world science in this field are summarized. A new model has been
created that allows us to consider the aging processes at the individual and
population levels from a single point of view on the main phenomenon of aging –
a decrease in the adaptive capabilities of the body with age. A mathematical
model of aging has been developed that is adequate for the entire life cycle of
an organism and reflects the fundamental features of changes in viability in
various phases of this cycle. A theoretical analysis of the problem of using
various models of aging (mortality) to optimize gerontological
experiments has been carried out. Approaches have been found to significantly
reduce the testing time of aging prevention products and the amount of research
required.
The created models make it possible to mathematically
describe the aging processes, predict the effects of geroprotectors
and put geroprophylaxis on a reliable quantitative
basis. In particular, model studies of various theories of aging have shown
that the most significant is the regulatory mechanism of aging and pointed to
promising ways of geroprophylaxis.
New experimental
data and knowledge
• on the mechanisms of
anti–aging effects of immunomodulators - A new immune theory of aging:
the ability of T-lymphocytes to directly stimulate the growth of somatic cells
of the body,
• about the effects and
mechanisms of action of a number of potential
geroprotectors
of the domestic school, little known abroad, such as: Transfer factor,
Alpha-fetoprotein, Galavit; Ascorbic acid, Diasponin, Hypoxytherapy, etc.;
• about age-destabilizing
changes in indicators of the
systemic integrity of the body – the internal structure of connections;
• on the possibilities of reversing the aging processes in mammals: age-related
immunodeficiency (mice) and memory (rabbits) with the help of transplants of
the hypothalamus centers.
• NGC specialists were the first in
• Mathematical
methods have been developed to
assess the rate of aging in various age periods by assessing age-related
changes in the intensity of human mortality. The historical stability of the
human aging rate is shown with a pronounced (tenfold) decrease in the total
mortality of the population. It is shown that for the first time in history, since
the middle of the twentieth century, there has been a decrease in the rate of
human aging, mainly in middle and old age, which, in our opinion, is associated
with the success of healthcare in the field of prevention of age-related
diseases. This point of view is confirmed by the Theoretical model of the aging
process developed by us with the allocation of aging syndromes similar to
disease syndromes, which allows us to understand and recognize the possible
impact of age-related disease therapy on the actual human aging process, which
opens up ways to create a new generation of geroprotection
based on well-tested means of treatment and prevention of age-associated
diseases.
Age dynamics, sex differences, nonlinear effects and psychophysiological correlates of mental performance were
studied. As a result of the analysis of
data from a 10-year experiment to study the dynamics of indicators of mental
performance (MP) and sensorimotor coordination (SC)
using the computer system "SOPR-monitoring", it was confirmed that
these indicators, widely used as markers of bio-age, in addition to age, can be
systematically influenced by other factors. It is shown that circadian and circannular periodic components may be present in the
dynamics of MP and SC indicators. The presence of correlations between the
indicators of MP and SC with cortisol levels suggests
that periodic components in the dynamics of performance may be due to the
influence of rhythms of hormonal regulatory systems. Taking into account the
revealed nonlinearities, the characteristics of the age dynamics of MP and SC
in men and women are clarified. The results obtained should be taken into
account when planning experiments aimed at studying the age dynamics of mental
performance.
• The analysis of the relationship between life expectancy (life expectancy) and healthy life expectancy (life
expectancy) in the countries of the world. As a result of statistical analysis
of WHO and UN data, it has been shown that for developing countries, where
infectious diseases make a large contribution to the risk of death, the
increments of OPW and OPW are almost equal. In developed countries, the
resources to reduce the loss of a healthy life by reducing infectious diseases
are largely exhausted. A decrease in mortality in severe forms of diseases
leads to an increase in the loss of a healthy life, i.e. to the
multidirectional changes of the OPCW and OPCW. This group of countries is
characterized by a small but steady decrease in low, compared with less
developed countries, age-related death risks in almost all age groups. At the
same time, the pronounced effects of the growth of OPF are delayed in time. The
results obtained show that the demographic effects of the development of
medicine can vary greatly depending on the initial age structure of the
population, age-related risks of death and the structure of morbidity. This
should be taken into account when implementing the achievements of healthcare
in highly developed countries in countries with a different medical and social
situation.
• An analysis of mortality rates in developed
countries in the twentieth century has been carried out. The phenomenon of a
decrease in the rate of aging in the second half of the twentieth century was
discovered. Possible causes of this phenomenon are discussed, which open up
possibilities for controlling the rate of aging.
• The analysis of the concept of human potential and methods
of its measurement is carried out. A comparative cross-country analysis of the
historical dynamics and trends in the development of demographic
characteristics of the human potential of
Applied results
of NGC:
A new method and means of stimulating the
body's antioxidant system, electrochemically activated systems (EHAS), have
been created. (https://www.elibrary.ru/item.asp?id=13380312) Under the
leadership of the President of the NGC, Corresponding member of the
New geroprophylactic and bioactivating
effects of the drug "Transfer factor" have been studied. The effects
of biostimulation and reduction of biological age
have been shown in mouse experiments and human studies. Patents were obtained
on "A method for restoring the cellular growth potential of tissues
decreasing with age" (Patent
for invention RU 2400239 C2, 09/27/2010. Application No. 2007125212/14 dated
07/04/2007.) and "Method for reducing biological
age" (Patent for invention RU
2404784 C2, 11/27/2010. Application No. 2007125208/14 dated 07/04/2007.).
Different geroprotectors differ significantly in terms of cost/effect.
Very cheap and effective geroprotectors have been
identified. For example, geroprotective effects have
been shown in the well–known ascorbic acid and the lipid-lowering drug diasponine.
Families of computer
systems (more than 20 systems) of
professional (for doctors) and popular (for home and family) levels have been
created, automating the processes of diagnosis and prevention of aging, as well
as increasing the functional reserves of the body. Among them are professional
systems: "Diagnostics of aging: bio-age" (determination of biological
age and aging profile), "Prevention of aging" (assistance to a doctor
in choosing geroprophylaxis technologies);
"Nutrition for health and longevity" (assessment and optimization of
diets); The "Mental performance assessment system" (as an important
biomarker of aging – this system was used in the international space experiment
"Mars-500"), etc. For mass use (for home and family), a set of
programs has been prepared for the assessment and selection of nutrition,
diagnosis and correction of stress, assessment and correction of physical and
mental performance, individual aging diagnostic systems and a number of others.
The Project "Intelligent digital platform for personalized
quality of life management "Health
Heuristics" is being developed.
The project received support from the National Technology Initiative. Project
objectives:
• Creation of an intelligent platform that provides
personalized quality of life management based on automated collection and
comprehensive analysis of multimodal data about a person, his lifestyle and the
environment.
• Creating an intelligent digital environment for manufacturers
and users of wellness services and products.
• Within the framework of the project, a series of
computer systems and applications for smartphones are
being created in order to analyze and monitor individual health. Modern methods
and approaches are used in the development of systems, including Big Data work
and methods of Artificial Intelligence and Neural Networks.
A hardware and software complex SKETCH (Expert Systems for Monitoring Individual Health)
has been created, designed to informatively support the main functions of a new
type of
A new
generation of devices (virtual devices - VD) has been created for
education and science, as well as websites and programs for remote
self-diagnosis of health and maintenance of various types of work activity of
the elderly and disabled.
A number of methodological recommendations and manuals for doctors have been developed and
approved by the Ministry of Health of the Russian Federation, in particular:
"Diagnosis and treatment of chronic fatigue syndrome",
"Quantitative assessment of aging, life expectancy and biological
age"; "General approaches to the prevention of aging";
"Optimization of preventive, health and geroprotective
diets using a computer system "Nutrition for health and
longevity"" etc.
A systematic
analysis of the characteristics of mortality
from the most socially significant diseases in the regions of
A new method of
comparative mortality analysis for a
group of populations has been developed, based on ranking populations by
mortality rate for each of the considered age ranges and calculating the rank
indices of age mortality. The advantage of this method in comparison with the
analysis of life expectancy, which is a convolution of age-related death risks,
or age-related mortality rates, the values of which for different age groups of
the same population may differ by several orders of magnitude, is the
possibility of simultaneous visual display of differences in the risk of death
in all age groups.
A comprehensive
method for evaluating normal aging in an experiment
in mice has been created for the purpose of a comprehensive quantitative
assessment of the aging process on an experimental model and evaluation of the
effect, mechanism and spectrum of action of geroprotectors;
in particular, at the cell level using the method of fluorescent probes and at
the level of the whole organism – using specially designed virtual devices.
Based on the
Systemic Theory of Aging , the basic mechanisms of
aging are identified and the means of influencing them are systematized.
Scientific and
organizational activities of the NGC
NGC specialists participated in the organization and
holding of more than 20 international and All-Russian conferences on
gerontology, health and restorative medicine: "Biomedical issues of normal
and pathological aging" Moscow, 1994; VI International Scientific and
Practical Conference "Topical issues of hygiene". February
27,
NGC specialists
have actively participated in more than 40 international and All - Russian
symposiums and conferences: "Biological mechanisms of aging" (Kharkiv, 1996), "Symposium of Human Health and
non-ionizing radiation" (Ljubljana, 1996), "The First Russian
Congress on Pathophysiology" (Moscow, 1996),
International Symposium “Nutrition and Health: biologically active food
additives" (Moscow, 1996), "World Congress of Gerontology"
(Adelaide, 1997), "1st Eutopean Conference on
Sustainable Island Development" (Minorka, 1997),
"Gordon Research Conference on the Biology of Aging" (Ventura, 1997),
"First European congress on Biogerontology"
(Denmark, 1998), "17 th World Congress of
Gerontology of the International Association of Gerontology" (Vancuver, 2001), "VI-th
European Congress of Clinical Gerontology» (Moscow, 2002), «18th World Congress
of Gerontology» (Rio de Janeiro, Brazil, 2005), «VI European Congress of the
International Association of Gerontology and Geriatrics (Saint Petersburg,
2006), «7th European Congress of Biogerontology»(Palermo,
2010), «Strategies for Engineered Negligible Senescence (SENS)» (Cambridge, UK,
2007, 2011) «VI Moscow International Congress "Biotechnology: State of the
Art and Prospects of Development". (
NGC specialists
are editors of the yearbook "Prevention of Aging" and the monographic
series "Problems of Gerontology", members of the editorial boards of
scientific journals: "Bulletin of Restorative Medicine",
"Proceedings of the Institute of Systems Analysis of the Russian Academy
of Sciences", "International Free Access"Medical
Journal", "Frontiers in Genetics of Aging", "Advances in
Aging Research", "World Journal of Translational Medicine",
"International Journal of Clinical Medicine".
They
participate in the activities of a number of scientific councils. For example,
Prof. V.N.Krutko:
• Chairman of the section "Applied
Gerontology" of the Scientific Council of the
• Member of the section "Gerontology and
Geriatrics" of the Academic Council of the Ministry of Health of the
• Member of the Board of the Association of
Rehabilitation Medicine Specialists;
• Member of the Problem Commission "Fundamentals
of Individual and Public Health" at the Presidium of the
• Member of the Scientific Council of the
Interregional Public Organization (NGO) "Scientific Medical Society of
Gerontologists and Geriatricians";
• Chairman of the Scientific Council of the National Gerontological Center; member of the Scientific Council of
the Institute of System Analysis of the Russian Academy of Sciences; member of
the Dissertation Council D002.086.02 at the Institute of System Analysis of the
Russian Academy of Sciences.
Educational
activities are underway. The program of the cycle of thematic improvement for
doctors "Prevention of aging as a new direction of hygienic science and
practice" was developed and officially approved at
NGC specialists
participated in the development of 11 programs and concepts at the federal
level, including: The Concept of the State Program for the Protection and
Promotion of Public Health, the Comprehensive Program for the Development of
the Soviet Arctic for the future up to 2000, the Concept of Environmental
Safety of Russia, the Concept of Sustainable Development of Russia, the Concept
of information support and the structure of the system for evaluating the
effectiveness of programs to reduce child mortality mortality
in the regions of the country, the Federal program "Older
Generation", the Federal target program "Active longevity".
Thanks to all
these above-mentioned works, the foundations of a new Technology for the prevention
of aging were laid, including: computerized procedures for determining the rate
of natural aging of both the body as a whole and its individual subsystems;
assessment of risk factors; determination on this basis of the expected life
expectancy of a person; selection of an individual configuration of means of
restraining aging processes and assistance in the application of these means in
everyday practice. The fundamental novelty of this Technology lies in focusing
on the diagnosis and correction of not specific diseases, but the deep
processes of wear and exhaustion of functional reserves of the body during
normal life, occurring in an absolutely healthy body. The technology surpasses
the available foreign analogues for solving this problem:
Ø in the general methodology (author's
development of a systemic theory of aging and a complex multilevel scheme of geroprophylaxis);
Ø in the diagnostic algorithm (the ability to
determine both the integral biological age and the partial ages of individual
body systems and calculate life expectancy, as well as the functional reserves
of the body and the risk of death);
Ø the use of a wide range of computer systems
for the diagnosis and prevention of aging, in particular, a computer system for
optimizing individual diets that slow down aging;
Ø in the methodology of selecting and applying
the configuration of aging deterrents (an integrated technology of simultaneous
exposure to the main aging processes of various levels is used);
The results of the work of the NGC aimed at the
development of aging prevention as a new area of medical science and practice
were reported at a meeting of the Presidium of the Russian Academy of Sciences
(see Bulletin of the Russian Academy of Sciences, 2006, No. 9, pp. 790-798.
https://elibrary.ru/item.asp?id=9433942 ), where they
received a high rating. The project "The concept and mechanisms for the
implementation of the innovative program "Active longevity of
The results of fundamental scientific and applied
research are reflected in 30 books, collections of works, textbooks for doctors
and patents, more than 300 articles in leading scientific journals (Frontiers
in genetics, Aging cell, Atlas of Science, Biogerontology,
Biology Bulletin, Human Physiology, Advances in Intelligent Systems and
Computing, Biophysics, Doklady Biological Sciences,
Mutation Research, Longevity Report, Rejuvenation Research, Advances in
Gerontology, Proceedings of the Russian Academy of Sciences, Bulletin of the
Russian Academy of Sciences, Reports of the Academy of Sciences, Biophysics,
Biochemistry, Human Physiology, Bulletin of Restorative Medicine, Bulletin of
Experimental Biology and Medicine, etc.) and reports at Russian and
international congresses. The monographic series "Problems of
Gerontology" is being published - 8 books of this series have been
published. The main results have been published, in particular, in books such
as:
1. "Immunobiology of
postnatal development"
2. "Fundamental mechanisms of geroprophylaxis",
2. "Aging: mechanisms and ways of
overcoming",
3. "Mathematical foundations of
gerontology",
4. "Informatics of health and longevity",
5. "Pathophysiological
mechanisms of chronic fatigue syndrome",
6. "Aging, longevity and bioactivation",
8. "Systemic mechanisms and models of
aging"",
9. "Analysis of trends in mortality and life
expectancy of the Russian population at the end of the twentieth century",
10. "Anti–aging medicine: fundamental
foundations",
11. "Human capital: a problem and a resource for
innovative development of
12. "Experimental gerontology - methods of
studying aging."